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[3] Orforglipron was approved for medical use in the United States in April 2026

PMCID: PMC3212886.

Pregnancy or breastfeeding, since it is unclear if these drugs are safe for those groups

At the same time, it can promote protein synthesis and fat storage, increase patients' weight, and enhance their physical resistance

Because of that, the NICE recommendations lean towards individualised care: tailoring the dose, frequency and delivery method, following people up at around three months, and reviewing sooner if symptoms are severe or if someone is pregnant or breastfeeding
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